Lu-177 DOTATATE + Sunitinib in PNETs

Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

IDENTIFIER (ClinicalTrials.gov): NCT05687123

DRUG/TREATMENT: Lu177 dotatate + sunitinib study

PHASE: 1

STATUS: Recruiting

SPONSOR: National Cancer Institute (NCI)

DESCRIPTION:

This phase I trial tests the safety, side effects, and dosimetry of sunitinib malate in combination with lutetium Lu 177 dotatate in treating patients with pancreatic neuroendocrine tumors. Sunitinib malate is in a class of medications called kinase inhibitors and a form of targeted therapy that blocks the action of abnormal proteins called VEGFRs that signal tumor cells to multiply. This helps stop or slow the spread of tumor cells. Radioactive drugs, such as lutetium Lu 177 dotatate, may carry radiation directly to tumor cells and not harm normal cells. It is also a form of targeted therapy because it works by attaching itself to specific molecules (receptors) on the surface of tumor cells, known as somatostatin receptors, so that radiation can be delivered directly to the tumor cells and kill them. Giving sunitinib malate and lutetium Lu 177 dotatate in combination may be safer and more effective in treating pancreatic neuroendocrine tumors than giving either drug alone.

For more information on eligibility criteria, trial locations, study details, etc., go to ClinicalTrials.gov to view this trial here.

CONTACT:

Principal Investigator:

Nikolaos Trikalinos,Yale University Cancer Center LAO

RELATED RESOURCES

Clinical Trials Using Lutetium Lu 177 Dotatate - NCI